Manifestations of copper excess
نویسندگان
چکیده
منابع مشابه
Mechanism and Effect of Excess Copper Supplementation on Body Lipids
Four rat experiments were done to determine the effect of copper supplementation, in excess of the rat’s nutritional needs, on body weight and blood and liver lipids. Excess copper in the form of gluconate or yeast had no effect on weight gain. It significantly diminished the concentration of serum cholesterol and serum triglycerides. Excess copper raised the concentration of serum high density...
متن کاملMitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess
The essential micronutrient copper is tightly regulated in organisms, as environmental exposure or homeostasis defects can cause toxicity and neurodegenerative disease. The principal target(s) of copper toxicity have not been pinpointed, but one key effect is impaired supply of iron-sulfur (FeS) clusters to the essential protein Rli1 (ABCE1). Here, to find upstream FeS biosynthesis/delivery pro...
متن کامل“The Perils Of Excess”: Wilson’s Disease ----A Copper Connection
Wilson’s disease aka progressive hepatolenticular degeneration is an unwonted genetic disorder of copper metabolism. Though its pathogenic inception lies within the hepatobiliary system, the brunt of relentless copper accretion is borne across a multisystemic terrain. The complex symptomatology of this syndrome mandates a high index of suspicion as left undiagnosed it has a tenacious progressio...
متن کاملAnalysis of Copper-Binding Proteins in Rice Radicles Exposed to Excess Copper and Hydrogen Peroxide Stress
Copper (Cu) is an essential micronutrient for plants, but excess Cu can inactivate and disturb the protein function due to unavoidable binding to proteins at the cellular level. As a redox-active metal, Cu toxicity is mediated by the formation of reactive oxygen species (ROS). Cu-binding structural motifs may alleviate Cu-induced damage by decreasing free Cu(2+) activity in cytoplasm or scaveng...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 1998
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/67.5.1069s